Throughout the world, millions of wild species and products are illegally collected, used, traded and exported. Tanzania’s Ruaha landscape is considered a critical area for biodiversity, as well as an area where poaching exists. Despite the area being rich in abundance and diversity of wildlife, indepth analysis of wildlife species hunted most and the methods used by poachers is lacking. This study assessed the most hunted wildlife species, extracted products and uses, and associations between wildlife products, hunting methods, and