Giraffe Skin Disease (GSD) is a recently observed illness, mainly affecting adult and subadult giraffes, causing gray or crusty lesions on giraffe body. The general objective of this study was to assess and characterize GSD and its severity in Tarangire-Manyara Ecosystem (TME). The study used road transects to gather field information on GSD. Eighty-four giraffes were sighted by systematic random sampling in the six study sites. Examination of giraffes involved body distribution of lesions, severity of the lesions and whether