A 6.5-YEAR-OLD female reticulated giraffe (Giraffa camelopardalis) was examined at the Columbus Zoological Park for acute abdominal pain of 3 hours’ duration. Signs of colic included kicking at the abdomen, lying down frequently for short intervals, and distention of the right paralumbar fossa. Rectal temperature was 37 C, heart rate was 28 beats/min, and respiratory rate was 12 breaths/min. The giraffe weighed approximately 550 kg and had been fed a herbivore diet containing approximately 10% protein. Flunixin meglumine8 (600 mg)