A study was conducted to examine the prevalence and epidemiological factors of a novel skin disease in giraffes inhabiting the Ruaha National Park (RNP). A cross-sectional drive-transect survey was conducted. Animals were observed using binoculars from the car. Potential epidemiological risk factors assessment included disease status, age, sex, disease severity, body condition, herd size, location, park zone, vegetation types, other wild animal species and presence of oxpeckers. The results showed that the prevalence of the skin disease was 79.8% and