Front foot radiographs from 22 giraffe (Giraffa camelopardalis reticulata) at one zoo were analyzed to better understand causes of lameness in this giraffe population. The herd had a history of front hoof overgrowth and intermittent lameness. Radiographic findings included distal interphalangeal joint osteoarthritis (OA), distal phalangeal bone (P3) osteitis, P3 fractures, P3 rotation, and sesamoid bone cysts. OA of the distal interphalangeal joint occurred in at least one front foot of 73% (16/22 giraffe) of the herd, and all giraffe