Developing techniques to quantify the spread and severity of diseases afflicting wildlife populations is important for disease ecology, animal ecology, and conservation. Giraffes (Giraffa camelopardalis) are in the midst of a dramatic decline, but it is not known whether disease is playing an important role in the broad-scale population reductions. A skin disorder referred to as giraffe skin disease (GSD) was recorded in 1995 in one giraffe population in Uganda. Since then, GSD has been detected in 13 populations in