Purpose of Review: The objective of this review is to present comparative echocardiography as a source of insights for human cardiovascular medicine. Recent Findings: We present echocardiographic examples of high impact human cardiovascular pathologies, including valvular, vascular, conduction, and myocardial disorders, in a wide range of species in varying environments. Unique features associated with comparative echocardiographic assessments are linked to human cardiology, including natural animal models of resistance and vulnerability. Summary: The cardiovascular vulnerabilities and strengths of other species can