Malnutrition is a common cause of morbidity and mortality in captive giraffe (Giraffa camelopardalis). Frothy bloat, a nutrition-related disease of domestic ruminants, has not previously been reported in Giraffidae. A 10-year-old female reticulated giraffe (G. c. reticulata) had a chronic cough and died in February 2007 following a two-month period of weight loss. Multiple nutrition-related abnormalities were identified post mortem: frothy bloat appeared to have been the immediate cause of death; there was no fibrous material in the forestomachs; and